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Detection of pre-cancerous (dysplastic) tissues in the clinic remains a challenge. Current methods often rely on systematic biopsies with no visual cues to guide the physician to areas likely to harbor dysplasia. We have developed a novel spectroscopic techniques for assessing cell structure and diagnosing disease based on combining interferometry with light scattering. Angle-resolved low coherence interferometry (a/LCI) combines the depth gating of coherence imaging with the high resolution structural information that can be obtained with light scattering spectroscopy. The a/LCI approach has been validated with in vitro measurements of phantoms and in vitro cells to recover structure with sub-wavelength accuracy and precision. Discrimination of pre-cancerous tissue states was initially demonstrated using animal models and ex vivo human tissues. We have developed a clinical a/LCI system, including an endoscope compatible fiber probe for in vivo measurements. The capabilities of a/LCI will be shown with results from clinical studies to detect precancerous cells in both the esophagus and cervix during routine clinical examination.
Instructor: Dr. Adam Wax