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These tutorials will overview recent advances in development and application of optical imaging techniques for structural and functional imaging and sensing of various transport, developmental, and disease progression in tissues and cells. This tutorial will start with basic description of light-tissue interaction including structural and optical models of tissues with single and multiple scattering. Intensity- and spatially modulated, coherent and polarized light interactions with random and quasi-organized tissues will be considered. It will be shown that light reflection, transmission, scattering, and state of polarization can be effectively controlled by changes of tissue structure and the refractive index of tissue components. Special emphasis will be devoted to theory and applications of novel imaging/sensing modality – Optical coherence Tomography (OCT). Many examples of OCT noninvasive sensing will be provided such as cardiovascular imaging, ophthalmic applications, monitoring of drug diffusion and optical clearing, sensing and quantifying of microbubbles and nanoparticles in tissues and blood, imaging of early embryonic cardiovascular system development, and, the newest hot topic, assessing biomechanical properties of tissues.
Engineers, scientists and physicians who are interested in learning optical imaging and spectroscopy, laser methods, OCT instruments design, and application for biomedical science and clinics will find this course useful. University education on the level of MS in engineering, physics, biophysics or medicine is required. Some basic prior knowledge of optics, statistics, histology and cell biology is desirable but not required.
Kirill V. Larin is an Associate Professor of Biomedical Engineering at the University of Houston. He also holds joint appointments at the Department of Physiology and Biophysics at Baylor College of Medicine and Department of Optics and Biophysics at the Saratov State University (Russia). Larin received his first M.S. in Laser Physics and Mathematics from the Saratov State University (1995), his second M.S. in Cellular Physiology and Molecular Biophysics (2001) and Ph.D. in Biomedical Engineering (2002) from the University of Texas Medical Branch in Galveston. Dr. Larin’s research contributions are in Biomedical Optics and Biophotonics and development and application of various optical methods for noninvasive and nondestructive imaging and diagnostics of tissues and cells (more information could be found on his lab webpage http://bol.egr.uh.edu). He has authored more than 80 peer-reviewed publications and chapters in six books on Biomedical Optics. Dr. Larin has received numerous awards including Presidential Award from Russian President Boris Yeltsin, Wallace Coulter Young Investigator Translation Award, Office of Naval Research Young Investigator Award, Outstanding Young Investigator Award from the Houston Society for Engineers in Medicine and Biology, Herbert Allen Award from American Society for Mechanical Engineers, and UH Research Excellence Award. Dr. Larin has delivered more than 50 invited and plenary talks, serves as a chair of Dynamics and Fluctuations in Biomedical Photonics and Optical Elastography conferences and a member of number technical committees at professional conferences. He is SPIE Fellow since 2015. Dr. Larin is also an Instructor for short courses on Tissue Optics and Biophotonics for the SPIE, IEEE, and OSA.
Instructor: Prof. Kirill Larin