Foundation “Dynasty” Short Course: The spectroscopy, surface modification and bio/medical applications of nanodiamond

Cheng 2014

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By Prof. Chia-Liang Cheng

National Dong Hwa University, Taiwan

Abstract

In this short course, we intend to introduce a newly emerged versatile nanomaterial, nanodiamond, and its promising bio and medical applications. The advantage of using nanodiamond as a nano-bio-probe compared to other nanoparticles (gold and quantum dots, etc.) will be the focus. First, we will start with a general introduction on nanoparticles used in life science applications, and an introduction on various instrumentation and methods of applications in biological systems. Then, we will cover the basic knowledge on the material, spectroscopic methods (Infrared, Raman spectroscopy and fluorescence measurements), the characterization and applications of nanodiamond. Finally, some implementations of nanodiamond in bio imaging will be demonstrated to show the promising bio and medical applications of nanodiamond. The whole short course is divided into three parts as the following.

Lecture 1: Nanoparticles and spectroscopic techniques used in life science applications. This section starts with an introduction on various nanoparticles, instrumentation and methods of applications used in bio imaging. Infrared, Raman and fluorescence techniques are illustrated with examples to explain how these techniques are implemented in life science measurements. Then, the advantage of using nanodiamond in bio and medical applications compared to other nanoparticles are demonstrated.

Lecture 2: Surface functionalization, characterization of nanodiamond prepared for bio and medical applications. The basic properties of nanodiamond as well as other carbon related materials such as diamond like carbon, carbon nanotubes and carbon nanostructures will be discussed. The surface functionalization/characterization and spectroscopic properties of various techniques will be covered. For bio and medical applications, the surfaces of nanodiamond are functionalized for further conjugation of biologically interested molecules such as proteins or drug. The nanodiamond serves as a biocompatible nano-label or transport vehicles of bio molecules into biological systems. The cytotoxicity of the nanodiamonds and the surface functionalization and characterization methods will be discussed in this section.

Lecure 3: Bio and medical applications of nanodiamond. In this section, we will demonstrate the bio application of nanodiamond. Nanodiamond conjugated with interested biomolecules to form nanodiamond-biomolecules complexes; the interaction of biomolecules with cells or bacteria is demonstrated using nanodiamond as a biocompatible labeling marker. The methods of using spectroscopic properties of nanodiamond such as Raman and fluorescence signals as a bio labeling marker for visualizing the bio interaction will be illustrated.

Learning objectives

This course will enable you to:

Intended audience

Engineers, scientists, and physicians who are interested in nanobiotechnology and nanomaterial application for medical science and clinics will benefit from this course.

Course level

Intermediate

Course Length

Half-day

Instructor

Chia-Liang Cheng is a professor in the Physics Department, and Vice President of National Dong Hwa University (NDHU), Hualien Taiwan. He received his Ph. D. degree from the Physics Department of the University of Oregon, USA in 1993. After obtaining his Ph.D. degree, he was a post-doc with Prof Y.T. Lee (Nobel Laureate in Chemistry, 1986) at the Chemistry Department in the University of California, Berkeley and Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei from 1994-1997. He was an assistant professor at Physics Department of the National Taiwan Normal University for one year, and then he joined NDHU in 1998. In 2005, he was promoted full professor. He is specialized in spectroscopy, and optical imaging. Currently, he is the Vice President of NDHU. His research interests are in Bio/medical applications of nanodiamond; spectroscopic studies on nanomaterial; visible-light-activated TiO2 nanoparticles; Infrared, Raman spectroscopy, etc. His interests go beyond the boundary of physics, chemistry, biology and medicine. His group is one of the pioneering groups in the world to successfully use nanodiamond as a biological marker to observe bio molecules interaction with cells or bacteria. They have recently delivered anticancer drug using nanodiamond as a delivery vehicle into lung cancer tumors in the animal model. He has been giving invited lectures in almost all the important diamond research conferences.

Personnel to contact with:

Instructor: Prof. Chia-Liang Cheng