Nanobiophotonics, Plenary Lecture

SILICON NANOPARTICLES FOR SENSITIVE FLUORESCENCE ANALYSIS IN LIVING CELLS AND DRUG DELIVERY CARRIED OUT BY MULTI DEPARTMENTAL AND INSTITUTIONAL COLLABORATIONS

Munir H. Nayfeh, Department of Physics, University of Illinois at Urbana-Champaign, USA

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ABSTRACT

Silicon nanoparticles are ultra-small, ultra-bright, and bio-compatible quantum dots which can be produced in commercial amounts at low cost with high repeatability of size, shape, and optical and electronic characteristics. Teams from several disciplines including biology, vet medicine, hospital, biophysics, material science, chemistry, and physics at Illinois have been collaborating to take this material from a laboratory curiosity to a viable technology for diagnosis and treatment of acute disease. The collaborations included also teams from other US and international institutions through US grants or bi-institutional grants. Applications include the use of the nanoparticles as a staining and contrasting agent for imaging stem cells, cancer cells and E. coli bacteria. Other applications include implantable detectors of biomedically important substances such as glucose as well as attachment to functional groups and labeling DNA and streptavidin protein. Finally encapsulation in polymers or carbon micro containers promises applications in drug delivery.

Representing author

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Prof. Munir Nayfeh

Department of Physics, University of Illinois at Urbana-Champaign
USA

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