Nanostructures, Oral Report

GRADUAL AND LASER INDUCED RELEASE OF MATERIALS FROM MULTILAYERED MICROCAPSULES

Anton Pavlov, Queen Mary, University of London, UK
Gleb Sukhorukov, Queen Mary, University of London, UK
Andre Skirtach, Max Plank Institute, Germany

ABSTRACT

Neuron cells uptake of biodegradable and synthetic polymeric microcapsules functionalized
with aggregates of gold nanoparticles incorporated into their shells is demonstrated in situ. In
addition to traditionally used optical microscopy, electron microscopy is used both for higherresolution
imaging and for confirming the uptake by focused ion beam cross-sectioning of
specific cells in situ. Subsequently, physical methods of release are compared to chemical
methods wherein laser-induced intracellular
release of dextran molecules into the cytosol
of hippocampal neuron cells is studied in comparison
to biodegradation. Implications of this
work for neuroscience, bio-medicine and
single cell studies are discussed.

Representing author

photo

Anton Pavlov

Saratov State University, Engineer
Russia

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