Biophotonics, Internet Invited Lecture

ASSESSMENT OF WAVE PROPAGATION IN MICE CORNEA IN SITU USING PHASE STABILIZED SWEPT SOURCE OCT

Ravi Kiran Manapuram, University of Houston, USA
Floredes M Menodiado, University of Houston, USA
Salavat Aglyamov, University of Texas at Austin, USA
Maleeha Mashiatulla, University of Houston, USA
Shang Wang, University of Houston, USA
Stanislav Emelianov,University of Texas at Austin, USA
Kirill V Larin, University of Houston, USA and Saratov State University, Russia

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ABSTRACT

In this paper, we extend the previously described phase resolved method to quantify wave propagation in mice lens ex-vivo to in-situ. The method utilizes M-mode imaging capabilities of a phase stabilized swept source optical coherence tomography (PhS-SSOCT) to quantify the wave propagation in mice cornea as a function of age. In-situ results confirmed our previous findings that the wave takes the shortest path in corneas to propagate. The results also showed that the measured wave propagation could be utilized to obtain the stiffness of the ocular tissue as a function of age. The method was further extended to measure velocities in rubber phantoms while exciting elastic waves using ultrasound. Phantom results also demonstrated that the velocities of elastic waves increased with the increase in stiffness of rubber phantoms. Obtained results also demonstrated that this method is capable of measuring velocities up to 30 m/s with a resolution of ~0.02 m/s. Therefore, this method could be utilized to quantify the parameters of wave propagation in soft tissues.

Representing author

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Mr. ravi kiran Manapuram

University of Houston, Student
Houston, USA

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