Timoshina P.A.(1), Vilensky M.A.(1), Alexandrov D.A.(3) , Tuchin V.V.(1,2,4), Kuleshov V.A.(3)
1- Saratov State University, Russia,2 - Institute of Precision Mechanics and Control, Russian Academy of Sciences, RAS, Saratov, 410028, Rabochaja str.,3- Saratov State Medical University, Russia,4-University of Oulu, Finland
The study of blood microcirculation is one of the most important problem for the modern medicine. Full field speckle-correlometry technique is a noninvasive contactless method that allows visualization of capillary blood flow in a real time without scanning of the laser beam. It is based on the analysis of contrast of time-averaged modulated speckle images. For monitoring the microcirculation of blood flow was developed laboratory model speckle -correlometer. The developed software allowed for real time calculations of the contrast spatial distribution from the experimental data obtained in the study of the dynamics of blood microcirculation in pancreas after local ischemia application . Received the results of experimental study of full field laser speckle contrast imaging of blood flow of the pancreas of laboratory rats. The obtained values of contrast of time-averaged speckle appropriate regimes of the microcirculation in the normal state and ischemia and reperfusion. It was found that the dynamic behavior of blood flow and vascular network studied by speckle imaging technique and digital microscopy is well match to physiological response to induced pathologies.
Ms. Polina Aleksandrovna Dyachenko /Timoshina/
Saratov State University, PhD, Engineer, Assistant
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