Chenxi Li, State Key Laboratory of Precision Measuring Technology and Instruments, TianjinUniversity,Tianjin, 300072, P. R.China
jingying jiang, State Key Laboratory of Precision Measuring Technology and Instruments, TianjinUniversity,Tianjin, 300072, P. R.China
kexin Xu, State Key Laboratory of Precision Measuring Technology and Instruments, TianjinUniversity,Tianjin, 300072, P. R.China
The optical reflectance spectrum has been widely adopted to extract diagnosis information with the advantages of non-invasive. In many applications, external pressure brought by fiber optic probe may influence properties and microcirculation of detecting tissue. According to the biphasic non-linear mixture model, human tissue is composed by the incompressible elastic solid and fluid. The behavior of tissue under compression is related to the deformation of the groundsubstance and fluid movement. Under certain local pressure, the spacing between tissue components and the refractive index mismatch decrease due to water displacement, while scatters’ concentration increased as the tissue is compressed. Therefore, the pressure-induced effects change tissue optical properties and influence the performance of reflectance spectrum. In this paper, a systematic study is focused on the effects of probe contact pressure on intrinsic changes of water and scattering particles in tissue. The objectives of the currently study were: (1) quantify the short and long term effects of probe contact pressure on diffuse reflectance; (2) study the mechanism of water transports under the compressed area; (3) employ the Finite Element and Monte Carlo method to simulate the deformation and reflectance spectrum changes of tissue before and after compression.
Prof. jingying jiang
Page views: 1068