Saratov Fall Meeting 2019, Plenary Lecture

EXOGENOUS FLUORESCENCE DIAGNOSTICS OF GASTROINTESTINAL TUMOURS

E. Borisova1, 2, A. Khorovodov2, I. Agranovich2, M. Kanevskiy2, S. Konnova2, Ts. Genova1, I. Angelov3, V. Mantareva3, N. Navolokin4, and O. Semyachkina-Glushkovskaya2

1 Institute of Electronics-Bulgarian Academy of Sciences, Sofia, Bulgaria, e-mail: borisova@ie.bas.bg
2 Biology Faculty, Saratov State University, Saratov, Russian Federation
3Institute of Organic Chemistry with Centre of Phytochemistry - Bulgarian Academy of Sciences, Sofia, Bulgaria
4Saratov State Medical University, Saratov, Russian Federation

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ABSTRACT

Gastrointestinal cancerous lesions were induced in laboratorial animals using prolonged exposure to social (overpopulation) and chemical stress (nitrosamine diet), mimicking typical stress factors for humans in the big cities. We studied effectiveness of 5-ALA/PpIX and differentphthalocyanine compounds as exogenous fluorescent markers of primary gastric carcinoma and in its metastases in other organs. Spectroscopic analysis was carried out on animals in vivo during open surgical procedure. Biochemical indicators detected malignant alterations presence in gastrointestinal tract were also evaluated and used as complementary tool for tumour diagnosis. Good correlation between spectral data and histology examination was achieved as well.
Acknowledgements: Work was supported by Russian Science Foundation project #18-15-00139.

Representing author

Dr. Ekaterina Georgieva Borisova

Institute of Electronics, Bulgarian Academy of Sciences, Associate Professor
Sofia, Bulgaria

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