Rinat Esenaliev, University of Texas Medical Branch, USA
In early 90s we proposed to use optoacoustics (photoacoustics) for biomedical applications and for more than 25 years have been working on it. In this invited talk we present our major biomedical optoacoustics achievements over these years. Optoacoustic diagnostic technique is based on thermoelastic generation of optoacoustic waves by short optical pulses. It combines high optical contrast and ultrasound spatial resolution. Since early-mid 90s we proposed to use the optoacoustic technique for a number of applications including cancer detection in breast, prostate, and other organs; hematoma detection and characterization; monitoring of thermotherapy (hyperthermia, coagulation, freezing); monitoring of cerebral blood oxygenation in adults, neonatal patients, fetuses during late stage labor; monitoring of central venous oxygenation and total hemoglobin concentration. We started from ideas, basic science, and first in vitro studies and in 1993 published the first peer-reviewed paper on biomedical optoacoustics. In mid 90s we demonstrated optoacousitc wave: 1) detection from tissues at cm-depths (well beyond the light diffusion limit); 2) detection from microscopic tissue volumes; 3) diffraction and attenuation effects in tissues. Then we reconstructed first optoacoustic images of tissue phantoms and tissues and then obtained first high-resolution optoacoustic images. We developed a number of optoacoustic methods and systems (including highly-compact laser diode systems) and tested them in small and large animal studies and in clinical studies in healthy volunteers and patients with traumatic brain injury, circulatory shock, and anemia as well as in neonatal and fetal patients. Recently, we proposed to use optoacoustic therapy and theranostics and tested them in a rat model of traumatic brain injury. Our data suggest that optoacoustics can be used for diagnostics, therapy, and real-time monitoring of therapeutic response as well as for follow-up after the therapy.
Prof. Rinat O. Esenaliev
University of Texas Medical Branch, Professor
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