Internet Biophotonics XI, Internet Invited Lecture

OPTICAL STUDY OF THE POSSIBILITIES TO AFFECT RBC AGGREGATION BY INHIBITION OF FIBRINOGEN ADSORPTION ON THE CELL MEMBRANE INTEGRIN GLYCOPROTEINS

A.E. Lugovtsov, Physics Departments and International Laser Center, M.V. Lomonosov Moscow State University, Leninskye Gory 1-62, 119991, Moscow, Russia
A.N. Semenov, Physics Departments, M.V. Lomonosov Moscow State University, Leninskye Gory 1-62, 119991, Moscow, Russia
K. Lee, Ulsan National Institute of Science and Technology, Institute of Basic Science, Center for Soft and
Living Matter, 44919, Ulsan, Korea
A.V. Myravyev, K.D. Ushinskiy Yaroslavl State Pedagogical University, Respublikanskaya street, 108/1, 150000, Yaroslavl, Russia
A.V. Priezzhev, Physics Departments and International Laser Center, M.V. Lomonosov Moscow State University, Leninskye Gory 1-62, 119991, Moscow, Russia

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ABSTRACT

Fibrinogen-induced red blood cells (RBC) aggregation was assumed to be caused by nonspecific binding of fibrinogen molecules to cell membranes and further leading to molecular bridging between interacting cells. In this work, we present the results of optical study of the effect of integrin IIb/IIIa glycoproteins inhibition on fibrinogen adsorption on RBC membrane.

The work was supported by the RFBR grants № 17-02-01200-a.

Representing author

photo

Dr. Andrei Egorovich Lugovtsov

International Laser Center of M.V. Lomonosov Moscow State University, Ph.D., reseacher
Moscow, Russia

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