Biophysics, Invited Lecture

AN ENERGY-RESOLVING X-RAY CAMERA AS A NOVEL TOOL IN THE FULL-FIELD X-RAY ANALYSIS OF MEDICAL AND BIOLOGICAL SAMPLES

O. Scharf Institut fuer Angewandte Photonik e.V. (IAP), Germany,
V. Arkadiev Institut fuer Angewandte Photonik e.V. (IAP), Germany,
R. Wedell Institut fuer Angewandte Photonik e.V. (IAP), Germany,
A. Bjeoumikhov IfG-Institute for Scientific Instruments GmbH, Germany,
S. Bjeoumikhova IfG-Institute for Scientific Instruments GmbH, Germany,
N. Langhoff IfG-Institute for Scientific Instruments GmbH, Germany,
S. Ihle PNSensor GmbH, Germany,
H. Soltau PNSensor GmbH, Germany,
I. Ordavo PNDetector GmbH, Germany,
G. Buzanich BAM Federal Institute for Materials Research and Testing, Germany,
R. Gubzhokov BAM Federal Institute for Materials Research and Testing, Germany,
M. Radtke BAM Federal Institute for Materials Research and Testing, Germany,
U. Reinholz BAM Federal Institute for Materials Research and Testing, Germany,
H. Riesemeier BAM Federal Institute for Materials Research and Testing, Germany

ABSTRACT

A new energy-resolving X-ray camera capable of energy- and space-resolved
measurements has been developed. This device consists of a high-speed CCD
detector coupled to Poly-capillary optics that conduct the X-ray photons
from the probe to distinct pixels onto the detector.
The pnCCD has an active area of 12.7 x 12.7 mm2, 264 x 264 pixels with 48 µm square
pixel size. The column-parallel and spilt-frame readout enable frame rates exceeding
400 Hz (equivalent to 28 Mpixel/s) and a maximum count rate of 620 kcps. The
spectroscopic performance at this speed is around 156 eV (FWHM) for Mn-Kα. The full
depletion of detector volume enables quantum efficiencies approaching 100 % in the 1
keV-10 keV energy range and is still amounting to 22 % for 24 keV photons.
The camera is capable of fast acquisition of spatially and energy resolved
fluorescence images. A dedicated software enables the acquisition and the online
processing of the spectral data for all 69696 pixels, leading to a real-time
visualization of the elements distribution in a sample.
We present measurements with synchrotron radiation and laboratory sources showing the
camera capability of performing full-field X-ray Fluorescence (FF-XRF), full-field
total-reflection XRF (TXRF), X-ray Diffraction (XRD) and X-ray fluorescence Tomography.
Examples from applications in biological sciences and medicine are given.

Representing author

photo

Dr. Oliver Scharf

Institute for Scientific Instruments
Germany

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