Short Courses, Lecture

OPTICAL COHERENCE TOMOGRAPHY: IMAGING AND SENSING OF TISSUES AND CELLS

Kirill V. Larin
University of Houston, Houston, USA,
Baylor College of Medicine, Houston, Texas, USA
Saratov State University, Saratov, Russia

ABSTRACT

In this short course I will overview recent advances in development and application of Optical Coherence Tomography (OCT) technique for structural and functional imaging and sensing of various transport, developmental, and disease progression in tissues and cells. This course will start with basic description of light-tissue interaction including structural and optical models of tissues with single and multiple scattering. Intensity- and spatially modulated, coherent and polarized light interactions with random and quasi-organized tissues will be considered. It will be shown that light reflection, transmission, scattering, and state of polarization can be effectively controlled by changes of tissue structure and the refractive index of tissue components. Various medical optical diagnostic and sensing methods and instruments based on CW, time-resolved, and spatially resolved light scattering spectroscopy and tomography, speckle interferometry, confocal, and two-photon microscopy, and polarimetry will be presented. Special emphasis will be devoted to theory and applications of OCT. Applications of these methods and techniques to control tissue and blood optical properties; to sense structure and image human tissues (such as skin, eye tissues, the body’s interior tissues, the cerebral membrane, bone, cartilage, and tendon) will be discussed. Additionally, this course will overview OCT-based methods for noninvasive monitoring of drug diffusion and optical clearing, sensing and quantifying of microbubbles and nanoparticles in tissues and blood, early diagnostics of arteriosclerosis, and imaging of early embryonic cardiovascular system development.

Representing author

photo

Prof. Kirill Larin

University of Houston, Professor
Houston, USA

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