Biophysics, Invited Lecture

DETECTION PERFORMANCE AS A DESIGN TOOL IN MUELLER IMAGING FOR CERVICAL CANCER

Meredith Kupinski, University of Arizona, USA; LPICM, CNRS, Ecole polytechnique, University Paris-Saclay, Palaiseau, France

ABSTRACT

In prior work a proof-of-concept study demonstrated significant contrast in Mueller polarimetric images acquired for healthy and pre-cancerous regions of excised cervical tissue. To quantify the ability of this modality to detect pre-cancerous tissue, polarimetric Mueller images of seventeen cervical specimens were compared to results from histopathology. The sensitivity and specificity of the new polarimetric technique were calculated for images acquired at 450nm, 550nm, and 600nm. The detection performance using only 600nm measurements yields a mean area under the receiver operating characteristic curve (AUC) of 0.89 which is the same detection performance as using all three wavelengths. Using 450nm and 550nm alone yields a lower AUC. This analysis yields insights into measurement utility and informs future imaging protocols.

Representing author

photo

Ms. Polina Aleksandrovna Dyachenko /Timoshina/

Saratov State University, PhD, Engineer, Assistant
Saratov, Russia

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