Biophysics, Plenary Lecture

ADVANCES IN LABEL-FREE OPTICAL ENDOMICROSCOPY TECHNOLOGIES TOWARDS HISTOLOGICAL IMAGING OF BIOLOGICAL TISSUES IN VIVO

Xingde Li
Department of Biomedical Engineering,
Department of Electrical and Computer Engineering, and
Department of Oncology
Johns Hopkins University

Discussion Live Chat

ABSTRACT

This presentation will focus on our recent progresses on developing high-resolution biophotonic imaging technologies, particularly the second-generation optical coherence tomography (OCT) endoscopy and multiphoton endomicroscopy. These technologies have shown promising translational potential for direct visualization of tissue microanatomies in vivo, in situ and in real time at a resolution from morphological to cellular, subcellular and ECM level, which approaches or at standard histopathology but without the need for tissue removal, staining or processing. The physics principles, engineering challenges and solutions will be briefly discussed, including the development of advanced lasers, MEMS technology, custom optical fiber, and ultracompact, high-performance imaging optics. Representative applications of these optical technologies will be presented, including cancer detection, small airway pathophysiology imaging, preterm birth risk assessment, and intra-operative guidance for neurosurgery. Other potential applications towards basic research such as functional neuroimaging on freely walking animals will also be discussed.

Representing author

photo

Prof. Xingde Li

Johns Hopkins University, Department of Biomedical Engineering, Professor
USA

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