Biophysics, Plenary Lecture

LASER SPECKLE MODELING AND SIMULATION FOR BIOPHYSICAL DYNAMICS

Kosar Khaksari, Department of Biomedical Engineering, Tufts University, Medford, MA 02155‎ USA

Sean J. Kirkpatrick, Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931 USA

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ABSTRACT

Laser speckle and related techniques play a significant role in the study of biophysical dynamics. This is partially due to the fact that speckle is a ubiquitous phenomenon that is observed whenever coherent radiation illuminates a rough surface or scattering volume. While this ubiquitous nature of speckle lends itself to easily implemented technologies for investigating complex biodynamics, it also makes proper interpretation of the results challenging. This presentation focuses on aspects of laser speckle including first – and second – order spatial statistics and their influences on the results of speckle-based measurements. Temporal statistics of time-varying speckle will also be discussed using a newly introduced approach of spatio-temporal Poincaré plots. The nature and potential applications of singular points, or optical vortices, in speckle fields will also be presented. A special emphasis will be placed on efficient computational techniques for the modeling and simulation of laser speckle. Applications of laser speckle to the estimation of blood flux, tissue perfusion, tissue mechanics and cellular activity will be discussed with an emphasis on suggesting universal guidelines on experimental techniques in an effort to make speckle measurements more repeatable and consistent between studies and between laboratories.

Representing author

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Dr. Sean J Kirkpatrick

Michigan Technological University, Chair & Professor of Biomedical Engineering
Houghton, MI, USA

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