Maria Savelyeva, Saratov State University, Russia
Anatoly A. Abalymov, Saratov State University, Russia
German P. Lyubun, Saratov State University, Russia
Ekaterina Prikhozhdenko, Saratov State University, Russia
Dmitry A. Gorin, Saratov State University, Russia
Bogdan V. Parakhonskiy, Ghent University, Belgium
Designing of composite materials consisting of a polymer and an inorganic component are explored intensively due to their potential for biomedical applications. The combination of well-known polymer properties (simplicity of processing and formation, improved mechanical properties) and inorganic moieties’ properties (biocompatibility, biodegradability, functional properties), supplemented with nanostructured morphology, allows beneficial applications in regenerative medicine to be realized.
In this study we fabricated the nanostructured composite based on electrospun polycaprolactone (PCL) fibers coated with porous calcium carbonate CaCO3. The structure of electrospun (ES) material is similar to natural extracellular matrix of living tissues; so ES fibers can be successfully used as tissue engineering scaffolds. The porous CaCO3 coatings on PCL fibers provide an ability of storage/release of functional cargo. CaCO3 in spherical porous polymorphic form, known as vaterite, is the suitable substrate for loading of various substances (nanoparticles, medicaments, growth factors, dyes). Modification, implemented with Ag nanoparticles, allows the SERS application with high enhancement factor of PCL/CaCO3 to be achieved.
In such way PCL/CaCO3 materials can be promising candidate for designing scaffolds provided with the function of cell growth control by incapsulated agent, supplemented by ability to detect biomolecules in scaffold by SERS.
Miss. Mariia Saveleva
Saratov State University, Postgraduate student
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