Anna Yaroslavsky, University of Massachusetts at Lowell, USA
Diagnostic accuracy of fine needle aspiration (FNA) remains a problem in cytopathology. A method to detect cancers at the cellular level would be helpful for assisting clinical decision making in FNA. Using an exogenous fluorophore, methylene blue (MB), in combination with confocal fluorescence polarization imaging, we were able to quantitatively discriminate cancer from normal cells. In particular, we investigated breast, brain and renal cancers. Significantly higher MB fluorescence polarization in cancer cells as compared to that in normal epithelial cells was observed. Our approach provides unique capability to detect cancer at the cellular level.
Prof. Anna N. Yaroslavsky
University of Massachusetts at Lowell
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