Biophysics, Poster

MONITORING OF EXPERIMENTAL TUMOR'S OXYGENATION AFTER RADIATION THERAPY USING DIFFUSE OPTICAL SPECTROSCOPY.

T.I. Pryanikova, Institute of Applied Physics of the Russian Academy of Sciences, Russia
A.G. Orlova,Institute of Applied Physics of the Russian Academy of Sciences, Russia
A.V. Maslennikova, Nizhny Novgorod State Medical Academy, Russia
G.Yu. Golubiatnikov, Institute of Applied Physics of the Russian Academy of Sciences, Russia
V.A. Kamensky, Institute of Applied Physics of the Russian Academy of Sciences, Russia
T.V. Smirnova, N.I. Lobachevsky Nizhny Novgorod State University, Russia
I.V. Turchin, Institute of Applied Physics of the Russian Academy of Sciences, Russia

ABSTRACT

Tumor oxygen state is considered to be one of the key factors influencing the malignant tumor prognosis and treatment effectiveness. Estimation of tumor oxygenation in the course of the therapy may be of great importance for choosing the optimal therapeutic strategies as well as for assessing treatment efficiency. In our work as a method of in vivo assessing the tumor oxygen status under the influence of treatment the method of diffuse optical spectroscopy (DOS) has been used. It is capable to provide information concerning blood oxygen saturation level which reflects the oxygen status of biological tissues. The goal of the current study was to investigate the dynamics of oxygenation of experimental tumors after radiation therapy by DOS. Tumors were irradiated with single dose of 10 Gy using gamma irradiation source. DOS procedures were performed before and after irradiation for 100 hours. After radiation therapy temporary increase of blood oxygen saturation in the tumor zone. As a verification method, parallel direct polarographic measurement of pO2 was carried out and the Spearmans correlation coefficient between pO2 and StO2 was calculated to be 0.86. Results obtained by polarographic and optical methods reflect the effect of tumor "reoxygenation" in response to radiation therapy.

Representing author

photo

Ms. Tatiana Pryanikova

Institute of Applied Physics of the Russian Academy of Sciences
Russia

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