Biophotonics, Internet Invited Lecture

PHOTODYNAMIC PROPERTIES OF NEWLY SYNTHESIZED POLYMER-PHTHALOCYANINE CONJUGATES

Ekaterina Borisova
Institute of Electronics, Bulgarian Academy of Sciences
72, Tsarigradsko Chaussee Blvd., 1784, Sofia, Bulgaria
Alexander Yakimansky
Laboratory of polymer nanomaterials and compositions for optic media,
Institute of Macromolecular Compounds, Russian Academy of Sciences,
Bolshoi pr. 31, 199004 St. Petersburg, Russia
Ivan Angelov, Vanya Mantareva
Institute of Organic Chemistry with Centre of Phytochemistry
Bulgarian Academy of Sciences, "Acad.G. Bonchev" str., Bl. 9
1113 Sofia, Bulgaria

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ABSTRACT

Biologically active photosensitizers (PS), such as phthalocyanines, with long wavelength of absorption are among the new generation drugs for photodynamic therapy (PDT). One of the most important tasks is related to optimization of photosensitizer delivery to the target cells, such as different human neoplasia. The cell specificity of the PS molecule is a very important property because during irradiation the toxic effect has to be limited to the tumor cells without harmful damages to the host healthy cells. The high PS selectivity is expected also to enhance the PDT efficacy. Newly-synthesized branched polymers from the researchers in the Institute of macromolecular compounds, are used as possible photosensitzers’ carriers and the absorbance, steady-state and time resolved fluorescence properties of the conjugates obtained with Zn-phthalocyanines were evaluated. The influence of temperature and pH on the conjugates photophysical properties are also investigated to obtain optimal conditions for the selective uptake of such developed complexes in biological cells for PDT applications.

Acknowledgements: This work is supported in part by the National Science Fund of Bulgarian Ministry of Education and Science under grant #DFNI-B02/9/2014 “Development of biophotonics methods as a basis of oncology theranostics”. E. Borisova personally acknowledged COST Action BM1205 “European Network for Skin Cancer Detection Using Laser Imaging”.

Representing author

photo

Dr. Ekaterina Georgieva Borisova

Institute of Electronics, Bulgarian Academy of Sciences, Associate Professor
Sofia, Bulgaria

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