Biophotonics, Internet Invited Lecture

PHOTONICS NON- AND MINIMALLY-INVASIVE DIAGNOSIS AND THERAPY OF DISEASES

Zeev Zalevsky; Faculty of Engineering, Bar-Ilan University, Israel
Yevgeny Beiderman; Faculty of Engineering, Bar-Ilan University, Israel
Javier Garcia; Departamento de O̔ptica, Universitat de València, Spain
Asaf Shahmoon; Faculty of Engineering, Bar-Ilan University, Israel

Discussion Live Chat Presentation (4.24 Mb)

ABSTRACT

In the first part of our talk we will present a technological platform that can be used for remote sensing of biomedical parameters and as a consequence to assist in remote diagnosis of diseases. The technology is based upon illuminating a surface with a laser and then using an imaging camera to perform temporal and spatial tracking of secondary speckle patterns in order to have nano metric accurate estimation of the movement of the back reflecting surface. If the back reflecting surface is a skin located close to main blood arteries then biomedical monitoring of various parameters can be realized. The main feature of this technology is that the same single sensor is used for sensing of many biomedical parameters simultaneously. The proposed technology was already applied for remote and continuous estimation of heart beats, respiration, blood pulse pressure, intra ocular pressure, blood coagulation, oximetry, remote estimation of alcohol and glucose concentrations in the blood stream, detection of fractions in bones and sensing of melanoma.
In the second part of our talk we will show our recent research involving the development of minimally invasive methodologies for imaging of internal organs. Here we introduce a new multi-functional microendoscope device suitable for nano therapy and capable of imaging of internal organs with minimally invasive intervention. The microendoscope device is a multi-core fiber having a total external diameter of only 100-200 microns and can provide high imaging resolution capability of more than 10,000 pixels (while each pixel is a different optical core). Nanometric channels fabricated between some of its cores allow injection of medical drugs. The diameter of each one of the cores can go down to 500nm resulting with a high spatial resolution capabilities used for detecting features having nanometer size. The microendoscope has been tested both in-vitro as well as in-vivo in rats presenting a promising and powerful tool as a high resolution and minimally invasive imaging facility suitable for previously unreachable clinical modalities. In addition to its super resolved imaging functionality, the micro endoscope can provide enhanced field of view, depth of focus as well as 3D capabilities to its user.

Representing author

photo

Prof. Zeev Zalevsky

Bar Ilan University
Israel

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