Department of Biomedical Engineering, Beckmann Laser Institute
The Edwards Life Sciences Center for Advanced Cardiovascular Technology
University of California, Irvine, Irvine, CA, USA
Atherosclerosis is one of the major causes of morbidity and mortality in developed countries. It is characterized by thickening of the arterial vessel wall due to atheromatous plaque which may result in narrowing or even occlusion of arterial lumen. Vulnerable plaques are subject to rupture, causing most cases of myocardial infarction and stroke. An imaging device that can provide high-resolution structure and molecular sensitivity will be essential for quantifying plaque vulnerability.
This presentation reports the development of integrated multiple modality intravascular imaging techniques for the identification and evaluation of venerable plaques. The integrated imaging modality combines high resolution capability of optical coherence tomography (OCT), deep penetration depth of intravascular ultrasound (IVUS), and molecular sensitivity of photoacustics (PA) and fluorescence imaging to quantify plaques. In vitro images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated probe, which demonstrated the feasibility of the integrated system in intravascular imaging and its potential in detection of vulnerable atherosclerotic plaques.
Prof. Zhongping Chen
Beckman Laser Institute, University of California
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