Daria K. Tuchina, Saratov State University, Russia
Optical methods of monitoring and treatments of tissue properties become more widely applicable in medicine. Functional imaging and monitoring of endogenous (metabolic) and exogenous chemical agents transport in biological tissues are under close attention of investigators during last decade. Permeability of tissues for different agents can give knowledge about mechanisms of tissue interaction with various chemicals, including metabolic molecules, drug transport within tissues, and impact of agents on tissue optical, morphological and functional properties. Agent’s permeability rate and optical clearing efficiency in tissue may indicate the presence of tissue pathology, such as diabetes mellitus.
As in diabetes the glucose level in blood is related to its level in the interstitial fluid, hyperglycemia contributes to metabolic imbalance and organs disorder, the structural change of tissue influences on its optical properties. Within this project the designing of technology for noninvasive optical monitoring of vital organ tissue pathology associated with diabetes development is proposed. The technology can be used for creation of the optical biosensor, which could determine the degree of tissue permeability and thus continuously monitor its condition.
Daria Kirillovna Tuchina
Saratov National Research State University, Assistant Professor, Engineer
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