Biophotonics, Internet Report

MONITORING OF MICROPARTICLE DELIVERY INTO SKIN IN VIVO

Elina A. Genina1, Alexey N. Bashkatov1, Irina Yu. Yanina1, Georgy S. Terentyuk1, Yulia I. Svenskaya1, Nikita A. Navolokin2, Leonid E. Dolotov1, Polina A. Timoshina1, Ekaterina A. Kolesnikova1, Vadim D. Genin1, Vasily Zaytsev1, Alla B. Bucharskaya2, Dmitry A. Gorin1, Valery V. Tuchin1, Gleb B. Sukhorukov3
1Saratov State University, Russia; 2Saratov State Medical University, Russia; 3Queen Mary University of London, UK

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ABSTRACT

In this report, we present results of monitoring of microparticle delivery into skin in vivo. CaCO3 microparticles and CaCO3 microparticles doped with Fe3O4 were synthesized. 14 white outbred laboratory rats were used in the study. Fractional laser microablation with different modes at the wavelength 2900 nm was used for creation of microchannels in rat skin with depth up to 300 um. Microparticles were introduced into the channels with massage. Optical coherence tomography at about 930 nm allowed visualizing microparticles inside tissue. Backscattering spectroscopy was used for analysis of the reflectance of the treated skin areas in the range 400-2100 nm. Monitoring of the skin areas was carried out during 7 days. Hystological samples were taken from the studied sites after measurements of all parameters. Results have shown that at the deep introduction, small amount of the particles can be registered in skin in a week.

Representing author

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Dr. Elina A Genina

Saratov State University, Associate Professor
Saratov, Russia

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