Biophysics, Poster

THE EFFECT OF LIGHT POLARIZATION ON THE EFFICIENCY OF PHOTODYNAMIC THERAPY

Mahshid JalalKamali
Semiconductor Department, Photonic Research Institute, International Center for Science, High Technology & Environmental Sciences (ICST), Mahan, Kerman, Iran,

Seyed Noureddin Nematollahi-mahani
Department of Anatomy, Afzalipour Faculty of Medicine, Kerman University of medical Sciences, Kerman, Iran,

Mohammad Shojaei Baghini
Afzal research institute, Kerman, Iran.

ABSTRACT

Photodynamic therapy (PDT) has been considered as a feasible cancer treatment. Especially, It is widely used in the field of skin cancers as a minimally invasive intervention. It consists of light application to tissues after administration of a photosensitizer drug that concentrates in the cancer cells. The reaction of light leads to the production of singlet oxygen that initiates the cell killing mechanisms.
During last decades, there has been a vast range of experimental and theoretical studies to optimize the whole PDT process and to minimize its adverse effects. This has been done by introducing new photosensitizers and using different and novel light sources and delivery systems. Also, the different parameters of light, including wavelength, energy density, power, duration and coherence has been investigated.
We are going to report an in vitro study of the effect of light polarization on the efficacy of the PDT treatment of cancer. In this cellular study, the BCC (basal cell carcinoma) cells has been chosen as the targets and and ALA is used as the photosensitizer. Different polarization states (nonpolarized, linearly polarized, circularly polarized and partially depolarized) of light sources has been investigated. We hope that the polarization can be considered as a fine tuning parameter to increase the PDT efficiency, while decreasing the required light levels and drug doses.

Representing author

photo

Mohammad Shojaei Baghini

Shahid Bahonar university of Kerman
Kerman, Iran

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