International School for Junior Scientists and Students on Optics, Laser Physics and Biophysics

Saratov Fall Meeting

SFM'12

September 25-28, 2012, Saratov, Russia

Optical Coherence Tomography: imaging and sensing of tissues and cells

Short course by Kirill V. Larin

University of Houston, Houston, USA,
Baylor College of Medicine, Houston, Texas, USA
Saratov State University, Saratov, Russia

Abstract

In this short course I will overview recent advances in development and application of Optical Coherence Tomography (OCT) technique for structural and functional imaging and sensing of various transport, developmental, and disease progression in tissues and cells. This course will start with basic description of light-tissue interaction including structural and optical models of tissues with single and multiple scattering. Intensity- and spatially modulated, coherent and polarized light interactions with random and quasi-organized tissues will be considered. It will be shown that light reflection, transmission, scattering, and state of polarization can be effectively controlled by changes of tissue structure and the refractive index of tissue components. Various medical optical diagnostic and sensing methods and instruments based on CW, time-resolved, and spatially resolved light scattering spectroscopy and tomography, speckle interferometry, confocal, and two-photon microscopy, and polarimetry will be presented. Special emphasis will be devoted to theory and applications of OCT. Applications of these methods and techniques to control tissue and blood optical properties; to sense structure and image human tissues (such as skin, eye tissues, the body’s interior tissues, the cerebral membrane, bone, cartilage, and tendon) will be discussed. Additionally, this course will overview OCT-based methods for noninvasive monitoring of drug diffusion and optical clearing, sensing and quantifying of microbubbles and nanoparticles in tissues and blood, early diagnostics of arteriosclerosis, and imaging of early embryonic cardiovascular system development.

Speaker

Kirill V. Larin is an Associate Professor of Biomedical Engineering at the University of Houston. He also holds joint appointments at the Department of Physiology and Biophysics at Baylor College of Medicine and Department of Optics and Biophysics at the Saratov State University (Russia). Larin received his first M.S. in Laser Physics and Mathematics from the Saratov State University (1995), his second M.S. in Cellular Physiology and Molecular Biophysics (2001) and Ph.D. in Biomedical Engineering (2002) from the University of Texas Medical Branch in Galveston. Dr. Larin’s research contributions are in Biomedical Optics and Biophotonics and development and application of various optical methods for noninvasive and nondestructive imaging and diagnostics of tissues and cells. The research projects in Dr. Larin’s laboratory are supported in part by grants from NIH, NSF, DOD, and industrial collaborators. Larin has authored more than 60 peer-reviewed publications and chapters in six books on Biomedical Optics. He has received numerous awards including Presidential Award from Russian President Boris Yeltsin, Wallace Coulter Young Investigator Translation Award, Office of Naval Research Young Investigator Award, Outstanding Young Investigator Award from the Houston Society for Engineers in Medicine and Biology, and Herbert Allen Award from American Society for Mechanical Engineers. Dr. Larin has delivered more than 20 invited and plenary talks, serves as a co-chair of Dynamics and Fluctuations in Biomedical Photonics conference and a member of number technical committees at professional conferences. He is also an Instructor for short courses on Tissue Optics and Biophotonics for the SPIE, IEEE, and OSA.

Contact

4800 Calhoun Rd., 3605 Cullen Blvd, Room 2028
Houston, TX 77204-5060
Phone: 832-842-8834
Email: klarin@uh.edu
http://www.egr.uh.edu/bol/

 

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